This may take some time to load. Poly(glycolic acid) (PGA) has a similar chemical structure to PLA but without the methyl side group, which allows the polymer chains to pack together tightly and results in a high degree of crystallinity (45–55%), high thermal stability (T m = 220–230 °C), exceptionally high gas barrier (3 times higher than EVOH), as well as high mechanical strength (115 MPa) and stiffness (7 GPa). The historical development of polyglycolic acid (PGA) and polylactic acid (PLA) polymers and copolymers for use in surgery is set down. The success of biomedical implants depends largely on four factors: their surface properties and. Terpolymers were synthesized with weight-average molecular weights over 65 kDa without catalyst. The chemistry of esters in general is reviewed and provides an introduction to the understanding of the processes that lead to the formation of polyesters and their subsequent hydrolytic degradation. The chemistry of the polymers, including synthesis and degradation, the tailoring of properties by proper synthetic controls such as copolymer composition, special requirements for processing and handling, and mechanisms of biodegradation will be covered. For this, the PECNs were produced initially by polyelectrolytic complexation (bottom-up method) and subsequently subjected to ultra-high pressure homogenization-UHPH (top-down method). Its unique properties have often been overlooked and are yet to be explored. Access scientific knowledge from anywhere. These hydrolytically unstable functional Join ResearchGate to find the people and research you need to help your work. An overview of biocompatibility and approved devices of particular interest in orthopedics are also covered. Harvested human fat and ADM/HA filler were injected randomly on the dorsal side of mice. biomedical applications due to insolubility of PGA in most of the solvents and rapid degradation of PGA. These results suggest that the woven fabric PGA may facilitate the formation of cartilage tissues by providing a biodegradable and good-handle vehicle for the delivery to and retention of organized cell matrix constructs in vivo site. interaction with adjacent tissue, their overall biocompatibility, their medically unobjectionable degradation, secretion and/or resorption and their mechanical strength. A strong, biodegradable, and biocompatible elastomer could be useful for fields such as tissue engineering, drug delivery, and in vivo sensing 1,2. The changes in porosity were observed with scanning electron microscopy and quantitatively assessed using image analysis. Poly(lactic acid-co-lysine) was synthesized and utilized for attaching a peptide containing the arginine–glycine–aspartic acid (RGD) sequence to enhance cell adhesion. The respective reactivity ratios of glycolide and lactide are elucidated. surfaces, laser processing has advantages in a dry processing which is able to process complex-shaped surfaces without using a toxic chemical component. The defect was filled with and without PGA under surgical condition. PEG (Mn = 8000 Da) was incorporated to reduce polymeric particle clearance rates by the immune system and improve particle resuspension and aerosolization efficiencies. In vitro and in vivo studies show the polymer has good biocompatibility. limit its use in other marketing applications in the industry. Both nondegradable polymers are designed to degrade in vivo in a controlled manner over a predetermined time. Biocompatibility is one of the most important requirements. We found that powder, granular, and fibrous materials made of polyglycolic acid (PGA) or polylactic acid (PLA) are very suitable for fluid-loss agents because PGA is stronger than steel and PLA is as strong as rock, although they dissolve as liquid acids after applications. Polyglycolic acid (PGA) is a desired material for physicians due to its If you are the author of this article you still need to obtain permission to reproduce All rights reserved. Molecular weight loss, gravimetric weight loss, pH changes and morphological changes were evaluated. Authors contributing to RSC publications (journal articles, books or book chapters) There were no significant microscopic differences in inflammatory changes and granulation via H&E staining. This chapter describes the chemistry of degradable polymers with a special emphasis on polyesters. By application, packing held a significant market share in 2019. groups can be hydrolyzed, or eaten by microorganisms, and degradability happens. 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